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Drug ReferencesEzetimibe; Simvastatin
NIACIN; SIMVASTATIN (NYE a sin; SIM va stat in) is used in combination with a healthy diet to lower bad cholesterol and raise good cholesterol.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
frequently drink alcoholic beverages
muscle aches or weakness
other medical condition
ulcers of intestine or stomach
an unusual or allergic reaction to niacin; simvastatin, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not crush, break, or chew. Take this medicine in the evening with a low-fat snack. Do not take this medicine with grapefruit juice, hot beverages, or alcohol-containing beverages. If you also take cholestyramine or colestipol, take this medicine at least 4 to 6 hours after your cholestyramine or colestipol dose. Take your doses at regular intervals. Do not take your medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Do not take this medicine with any of the following medications:
certain antibiotics like clarithromycin, erythromycin, telithromycin
certain antiviral medicines for HIV or AIDS
medicines for fungal infections like itraconazole, ketoconazole, posaconazole, and voriconazole
other niacin products
red yeast rice
This medicine may also interact with the following medications:
medicine for blood pressure or heart disease
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your doctor or health care professional for regular checks on your progress. You may need regular tests to make sure your liver is working properly.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
Do not drink hot drinks or alcohol at the same time you take this medicine. Hot drinks and alcohol can increase the flushing caused by this medicine, which can be uncomfortable.
This drug is only part of a total heart-health program. Your doctor or a dietician can suggest a low-cholesterol and low-fat diet to help. Avoid alcohol and smoking, and keep a proper exercise schedule.
If you are diabetic, close monitoring of your blood sugars can help your blood fat levels. This medicine may change the way your diabetic medicine works, and sometimes will require that your dosages be adjusted. Check with your doctor or health care professional.
Tell your doctor or health care professional right away if you get any unexplained muscle pain, tenderness, or weakness, especially if you also have a fever and tiredness. Your doctor or health care professional may tell you to stop taking this medicine if you develop muscle problems. If your muscle problems do not go away after stopping this medicine, contact your health care professional.
Do not use this drug if you are pregnant or breast-feeding. Serious side effects to an unborn child or to an infant are possible. Talk to your doctor or pharmacist for more information.
If you are going to have surgery tell your doctor or health care professional that you are taking this drug.
Some drugs may increase the risk of side effects from this medicine. If you are given certain antibiotics or antifungals, your doctor or health care professional may stop this medicine for a short time. Check with your doctor or pharmacist for advice.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
chest pain or palpitations
feeling faint or lightheaded, falls
fever or chills
high blood sugar, ask your doctor for symptoms
loss of memory
muscle cramps, pain
redness, blistering, peeling or loosening of the skin, including inside the mouth
stomach pain and loss of appetite
unusually weak or tired
yellowing of skin or eyes
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
stomach upset or bloating
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.